Modern regenerative therapies at NOVACELL CLINIC
At NOVACELL CLINIC, we offer individual qualification assessment for stem cell therapy for patients with chronic, difficult-to-treat urological conditions, such as:
- Stress urinary incontinence (SUI)
- Overactive bladder (OAB)
- Interstitial cystitis (IC/BPS)
These therapies are particularly considered recommended for patients who have not achieved improvement with standard treatment methods. Each patient undergoes a thorough qualification assessment process that, and the entire process is conducted in accordance with international safety and quality standards.
Urinary incontinence (UI)
Who are these therapies for? What is UI?
It’s an uncontrolled leakage of urine from the bladder, which can occur during physical exertion (e.g., coughing, laughing, lifting weights), a sudden urge to urinate, or even at rest. UI is prevalent in women, particularly after childbirth and during menopause, but can affect women of all ages.
Incidence
- It affects 10–40% of women, and even up to 50–60% of women after menopause
- In young women (20–29 years old) the incidence is estimated at 4.4%, and in those aged 60–70 years – even at 60%
- Many women don’t report symptoms due to embarrassment, so the actual number of cases may be higher
Symptoms
- Involuntary leakage of urine during exercise, coughing, or laughing (stress urinary incontinence)
- Sudden, hard-to-control urge to urinate (urinary tract infection)
- Frequent urination, also at night (nocturia)
- A feeling of incomplete emptying of the bladder
Treatment
- Conservative therapy: Pelvic floor muscle exercises (Kegel exercises), bladder training, lifestyle changes (weight loss, limiting caffeine and alcohol)
- Pharmacotherapy: Antimuscarinic drugs, adrenergic drugs, duloxetine, estrogens (in postmenopausal women)
- Surgical treatment: Procedures using synthetic tapes (so-called slings ), injections of bulking agents, urethral support surgeries
- Modern therapies: Stem cell therapy (e.g., MSC from Wharton's jelly) – a method offered to patients that have been unsuccessful with standard treatments. Studies show that stem cells can support tissue regeneration and improve sphincter function.
Overactive bladder (OAB)
It’s a set of symptoms that include sudden, uncontrollable urges to urinate, frequent urination (more than 8 times a day), nocturia, and sometimes urge incontinence. OAB is not associated with infection or other obvious pathology.
Incidence
- It affects up to 16–20% of adults, mostly women, especially after menopause.
Symptoms
- Sudden, strong urge to urinate
- Urge urinary incontinence (not always the case)
Treatment
- Behavioral therapy: Bladder training, pelvic floor exercises, diet and lifestyle modifications
- Pharmacotherapy: Antimuscarinics (e.g. solifenacin ), beta-3 agonists ( mirabegron )
- Other methods: Neuromodulation , botulinum toxin injections into the bladder.
- Regenerative Therapies: Stem Cell Therapy (MSC) – Preclinical studies have shown that MSCs can improve bladder function, reduce its overactivity, and support tissue regeneration.
Interstitial cystitis (IC/BPS)
What is IC?
IC/BPS is a chronic, debilitating disease characterized by pelvic pain, suprapubic pain, and urinary symptoms (urinary urgency, urinary frequency, nocturia), with no bacterial infection or other causes.
Incidence
- Much more common in women than in men (ratio 10:1)
Symptoms
- Chronic pain in the bladder and pelvic area, which intensifies when the bladder is full
- Frequent urination, also at night
- Sudden urge to urinate
- No infection in lab tests
Treatment
- Lifestyle modification: Bladder elimination diet, bladder training, relaxation techniques
- Physiotherapy: Pelvic floor muscle therapy, massages, relaxation techniques
- Pharmacotherapy: Antidepressants (e.g. amitriptyline), antihistamines, pentosan sodium polysulfate , painkillers, nonsteroidal anti-inflammatory drugs
- Local treatment: Intravesical infusions (heparin, lidocaine, DMSO), botulinum toxin injections
- Modern Therapies: Stem Cell Therapy (MSC) – Preclinical and early clinical studies suggest that MSCs may support bladder epithelial regeneration and modulate chronic inflammation. This therapy is still experimental but offers hope for patients who have been unsuccessful with standard treatments.
Summary & Top Tips
- Urinary incontinence, overactive bladder and interstitial cystitis are common, chronic conditions that can significantly reduce women's quality of life.
- Standard treatment includes conservative, pharmacological and surgical therapy, and in difficult cases – modern regenerative therapies, including stem cells.
- Stem cell therapy is safe, minimally invasive, and may be an opportunity for patients who have not achieved improvement after other treatments, yet it’sstill an experimental method that requires individual asessment.
- If you have any questions or want to find out if you qualify for regenerative therapy, contact the NOVACELL CLINIC team – we will guide you through the entire diagnostic and treatment process.
Remember
Each patient is different – every treatment is selected individually, and the decision about therapy is made together with the doctor after a detailed analysis of your case.
